EFFECT OF HYDROGEN SULPHIDE DONOR ON INTRAOCULAR PRESSURE IN RATS

Area of Science:

• Ophthalmology
• Physiology
• Pharmacology

Background:

• Intraocular pressure (IOP) regulation is crucial for ocular health.
• Ocular hypertension is a risk factor for glaucoma.
• The role of endogenous signaling molecules in IOP control is an active area of research.

Purpose of the Study:

• To investigate the effect of sodium hydrosulfide (NaHS), a hydrogen sulfide donor, on intraocular pressure (IOP) in rats.
• To evaluate the efficacy of NaHS in preventing or reducing IOP elevation during experimentally induced ocular hypertension.

Main Methods:

• A 1% sodium hydrosulfide (NaHS) solution was administered as eye drops.
• Intraocular pressure was measured in intact rats and in rats with experimentally induced ocular hypertension (using adrenaline).
• Both single and prolonged administrations of NaHS were studied.

Main Results:

• A single topical application of NaHS induced a hypotensive effect on IOP.
• This hypotensive effect was more pronounced in eyes with experimentally induced ocular hypertension compared to normotensive eyes.
• Long-term administration of NaHS largely prevented the rise in IOP during adrenaline-induced ocular hypertension.

Conclusions:

• Hydrogen sulfide plays a role in the regulation of eye hydrodynamics.
• Hydrogen sulfide contributes to maintaining normal intraocular pressure levels.
• NaHS demonstrates potential as a therapeutic agent for managing ocular hypertension.