Related Experiment Video
Updated: Feb 22, 2026
Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Pancreatic β-Cell Function and Prognosis of Nondiabetic Patients With Ischemic Stroke
Yuesong Pan1, Weiqi Chen1, Jing Jing1
1From the Department of Neurology, Beijing Tiantan Hospital (Y.P., W.C., J.J., H.Z., Q.J., H.L., X.Z., L.L., Yongjun Wang, Yilong Wang) and Department of Epidemiology and Health Statistics, School of Public Health (Y.P., Y.H.), Capital Medical University, China; China National Clinical Research Center for Neurological Diseases, Beijing (Y.P., W.C., J.J., H.Z., Q.J., H.L., X.Z., L.L., Yongjun Wang, Yilong Wang); Center of Stroke, Beijing Institute for Brain Disorders, China (Y.P., W.C., J.J., H.Z., Q.J., H.L., X.Z., L.L., Yongjun Wang, Yilong Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (Y.P., W.C., J.J., H.Z., Q.J., H.L., X.Z., L.L., Yongjun Wang, Yilong Wang); and Beijing Municipal Key Laboratory of Clinical Epidemiology, China (Y.P., Y.H.).
Background And Purpose:
Pancreatic β-cell dysfunction is an important factor in the development of type 2 diabetes mellitus. This study aimed to estimate the association between β-cell dysfunction and prognosis of nondiabetic patients with ischemic stroke.
Methods:
Patients with ischemic stroke without a history of diabetes mellitus in the ACROSS-China (Abnormal Glucose Regulation in Patients with Acute Stroke across China) registry were included. Disposition index was estimated as computer-based model of homeostatic model assessment 2-β%/homeostatic model assessment 2-insulin resistance based on fasting C-peptide level. Outcomes included stroke recurrence, all-cause death, and dependency (modified Rankin Scale, 3-5) at 12 months after onset.
Results:
Among 1171 patients, 37.2% were women with a mean age of 62.4 years. At 12 months, 167 (14.8%) patients had recurrent stroke, 110 (9.4%) died, and 184 (16.0%) had a dependency. The first quartile of the disposition index was associated with an increased risk of stroke recurrence (adjusted hazard ratio, 3.57; 95% confidence interval, 2.13-5.99) and dependency (adjusted hazard ratio, 2.30; 95% confidence interval, 1.21-4.38); both the first and second quartiles of the disposition index were associated with an increased risk of death (adjusted hazard ratio, 5.09; 95% confidence interval, 2.51-10.33; adjusted hazard ratio, 2.42; 95% confidence interval, 1.17-5.03) compared with the fourth quartile. Using a multivariable regression model with restricted cubic spline, we observed an L-shaped association between the disposition index and the risk of each end point.
Conclusions:
In this large-scale registry, β-cell dysfunction was associated with an increased risk of 12-month poor prognosis in nondiabetic patients with ischemic stroke.
Related Concept Videos
01:27Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are...
01:36Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
01:22Diabetes Mellitus: Type 2 and Gestational
01:22Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:25Insulin: Biosynthesis, Chemistry, and Preparation
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...