Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinicopathological features and cancer-specific survival in young patients with ulcerative colitis-associated colorectal neoplasia: a nationwide cohort study in Japan.

Inflammatory bowel diseases·2026

Same author

An extremely rare case of stercoral colitis with a subsequent benign stricture: preoperative thin endoscopic assessment to optimize surgical extent.

Clinical journal of gastroenterology·2026

Same author

Diagnostic and surgical challenges of a lymph node metastasis from occult gastric cancer mimicking a pancreatic head tumor: A case report.

Oncology letters·2026

Same author

Colitis-associated colorectal neoplasia in ulcerative colitis with primary sclerosing cholangitis: a nationwide study.

Intestinal research·2026

Same author

Comparison of long-term outcomes between proximal gastrectomy and total gastrectomy for advanced gastric cancer in the upper third of the stomach: a propensity score-matched analysis.

Japanese journal of clinical oncology·2026

Same author

ASO Visual Abstract: TRIM37 Expression is Associated with Immune Suppression, Poor Response to Neoadjuvant Chemotherapy, and Worse Survival in ER-Positive/HER2-Negative Breast Cancer.

Annals of surgical oncology·2026

Search research articles

Related Experiment Video

Updated: Feb 22, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Precision Cancer Medicine and Super-computing System.

Toshifumi Wakai¹

¹Division of Digestive and General Surgery, Niigata University, Niigata, Japan.

The Keio Journal of Medicine

|September 29, 2017

Summary

This summary is machine-generated.

Comprehensive Genomic Sequencing using CANCERPLEX-JP (435 genes) identifies molecular subtypes for targeted cancer therapy. This approach aligns with precision medicine goals, enhancing treatment strategies and drug discovery for solid tumors.

More Related Videos

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

Related Experiment Videos

Last Updated: Feb 22, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

Area of Science:

Oncology
Genomics
Bioinformatics

Background:

Tumor classification into molecular subtypes is crucial for effective cancer treatment.
Genomic sequencing, particularly comprehensive targeted-gene panels, offers expanded therapeutic options.
Precision medicine aims for cost-effectiveness and accelerated genome-driven drug discovery.

Purpose of the Study:

To evaluate the clinical utility of the CANCERPLEX-JP (435 genes) comprehensive targeted-gene panel.
To demonstrate the concordance of CANCERPLEX-JP with whole-exome sequencing in identifying key genomic alterations.
To support the integration of Comprehensive Genomic Sequencing into precision medicine strategies.

Main Methods:

Utilized the CANCERPLEX-JP version 4.0 gene panel to analyze Japanese and US cancer cases.
Assessed frequently altered genes and pathways in solid tumors.
Validated findings by comparing with whole-exome sequencing data from The Cancer Genome Atlas (TCGA).

Main Results:

CANCERPLEX-JP identified actionable genes and pathways relevant to targeted therapy.
Demonstrated concordance with whole-exome sequencing in detecting hypermutated samples and microsatellite instability in colorectal and gastric cancers.
Highlighted the clinical utility of the 435-gene panel in guiding treatment decisions for solid tumors.

Conclusions:

Comprehensive Genomic Sequencing with panels like CANCERPLEX-JP is vital for actualizing precision medicine.
This approach provides a strong rationale for guiding targeted therapy in solid tumors.
The findings support the broader adoption of genomic profiling for personalized cancer care and drug discovery.