Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oncogene expression in a medullary thyroid carcinoma.

M Klimpfinger1, C Ruhri, B Pütz

  • 1Institute of Pathology, University of Graz School of Medicine, Austria.

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
|January 1, 1988
PubMed
Summary

Oncogene expression, including Ha-ras, c-myc, and N-myc mRNA, was significantly elevated in medullary thyroid carcinoma. This overexpression in tumor tissue suggests a role in the initiation and progression of this thyroid cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response.

Translational psychiatry·2015
Same author

Activation of the PI3K/AKT pathway correlates with prognosis in stage II colon cancer.

British journal of cancer·2014
Same author

Bilateral leg edema in an older woman.

Zeitschrift fur Gerontologie und Geriatrie·2013
Same author

Chromium content of normal and pathologically altered lung tissue.

Biological trace element research·2013
Same author

MiR-221/-222 differentiate prognostic groups in advanced breast cancers and influence cell invasion.

British journal of cancer·2013
Same author

Renopathological Microstructure Visualization from Formalin Fixed Kidney Tissue by Matrix-Assisted Laser/Desorption Ionization-Time-of-Flight Mass Spectrometry Imaging.

Balkan journal of medical genetics : BJMG·2013

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor.
  • Understanding the molecular mechanisms, particularly oncogene expression, is crucial for MTC research.

Purpose of the Study:

  • To investigate the expression levels of specific oncogenes (Ha-ras, fos, c-myc, N-myc) in human medullary thyroid carcinoma.
  • To compare oncogene expression between primary tumors and lymph node metastases.
  • To evaluate oncogene expression relative to normal thyroid tissue.

Main Methods:

  • In situ hybridization and Northern blot analysis were employed.
  • Expression of Ha-ras, fos, c-myc, and N-myc mRNA was quantified.
  • Comparison between tumor tissue (primary and metastatic) and normal thyroid gland.

Related Experiment Videos

Main Results:

  • Significant overexpression of Ha-ras, c-myc, and N-myc mRNA was observed in MTC tissue compared to normal thyroid tissue.
  • No significant difference in oncogene expression was found between primary tumors and lymph node metastases.
  • Fos mRNA levels did not differ significantly, while sis, fms, and abl mRNA were undetectable.

Conclusions:

  • The overexpression of Ha-ras, c-myc, and N-myc oncogenes may be implicated in the initiation and progression of medullary thyroid carcinoma.
  • Further studies on additional MTC cases are warranted to confirm these findings.