CASTLE Thyroid Tumor: A Case Report and Literature Review

Area of Science:

• Endocrinology
• Oncology
• Pathology

Background:

• Carcinoma showing thymus-like differentiation (CTLD) is a rare thyroid neoplasm with a generally favorable prognosis.
• While radiotherapy is effective for local control, distant recurrence remains a concern.
• Adjuvant chemotherapy is hypothesized to reduce recurrence risk.

Observation:

• This report details a case of a patient with a large CTLD and extrathyroidal extension.
• The patient underwent a multidisciplinary treatment approach.
• Treatment included surgical resection, radiotherapy, and cisplatin-based chemotherapy.

Findings:

• The patient tolerated the combined treatment regimen with acceptable toxicity.
• After three years of follow-up, the patient remains disease-free from local recurrence or distant metastasis.
• This case suggests the efficacy of multimodal therapy in managing advanced CTLD.

Implications:

• This case highlights the potential benefit of adjuvant chemotherapy in conjunction with surgery and radiotherapy for advanced CTLD.
• Multimodal treatment may improve outcomes and reduce the risk of recurrence in these rare thyroid tumors.
• Further research is warranted to establish optimal treatment protocols for CTLD.