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Correlative Optical Spectroscopy and Mass Spectrometry Imaging Methodology to Visualise Drug Distribution in a Soft Tissue Section

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Vibrational spectroscopy and imaging: applications for tissue engineering.

William Querido¹, Jessica M Falcon, Shital Kandel

¹Department of Bioengineering, Temple University, Philadelphia, PA, USA. npleshko@temple.edu.

|September 29, 2017

Summary

This summary is machine-generated.

Vibrational spectroscopy, including Fourier transform infrared (FTIR) and Raman spectroscopy, offers non-destructive methods for assessing tissue engineered construct composition. These techniques provide crucial compositional data for evaluating tissue engineering (TE) strategies.

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Area of Science:

Biomaterials Science
Tissue Engineering
Spectroscopy

Background:

Tissue engineering (TE) aims to regenerate or replace tissues and organs.
Evaluating the composition of engineered tissues is critical for successful implantation.
Current destructive methods limit compositional assessment of tissue engineered constructs.

Purpose of the Study:

To review the application of vibrational spectroscopy in evaluating tissue engineered constructs.
To highlight the benefits of non-destructive compositional analysis in tissue engineering.

Main Methods:

Discussion of Fourier transform infrared (FTIR) spectroscopy (mid and near-infrared).
Discussion of Raman spectroscopy.
Focus on label-free, non-destructive vibrational spectroscopic techniques.

Main Results:

Vibrational spectroscopy provides specific chemical composition information.
Techniques are suitable for both in vitro and in vivo assessments.
Fiber optic and imaging capabilities enhance TE evaluations.

Conclusions:

Vibrational spectroscopy is a valuable tool for assessing tissue engineered construct composition.
Non-destructive analysis improves the evaluation process in tissue engineering.
Spectroscopic methods contribute significantly to the development of TE strategies.