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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Diabetic Nephropathy: a Tangled Web to Unweave
Corey Magee1, David J Grieve2, Chris J Watson1
1Centre for Experimental Medicine, Queen's University Belfast, Wellcome-Wolfson Building, 97 Lisburn Road, Belfast, Northern Ireland, BT9 7AE, UK.
Cardiovascular Drugs and Therapy
|September 29, 2017
Summary
Diabetic nephropathy (DN) is a leading cause of kidney failure. Novel therapeutics are needed as current treatments for this complex, multi-cellular disease only delay progression.
Area of Science:
- Nephrology
- Diabetology
- Pathology
Background:
- Diabetic nephropathy (DN) is the primary cause of end-stage renal disease globally, with increasing diabetes incidence suggesting pandemic potential.
- Hyperglycemia-induced vascular dysfunction initiates DN, but progression involves oxidative stress, inflammation, and fibrosis.
- Current treatments targeting glycemia and hypertension delay, but do not prevent, DN progression and its associated burdens.
Purpose of the Study:
- To review current therapeutic strategies for diabetic nephropathy.
- To explore how the multi-dimensional complexity of DN influences research and clinical translation of novel therapies.
Main Methods:
- Literature review of current therapeutic approaches for DN.
- Analysis of the pathological mechanisms driving DN progression.
- Discussion of challenges in clinical translation of basic DN research.
Main Results:
- DN is a complex, multi-cellular condition, not solely vascular.
- Numerous potential therapeutic targets have been identified in the genomic era.
- Clinical translation of basic research faces significant challenges.
Conclusions:
- There is a critical need for novel, effective, and safe therapeutics for DN.
- Understanding DN's complexity is crucial for developing successful treatments.
- Future research must address the multi-dimensional nature of DN for improved clinical outcomes.
Keywords:
Diabetic nephropathyInflammationNovel therapiesOxidative stressRenin-angiotensin-aldosterone systemVascular dysfunctionMore Related Videos
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