Related Experiment Video

Updated: Feb 22, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

675

RELATIONSHIP BETWEEN BLOOD ALDOSTERONE AND SOMATOMETRIC PARAMETERS IN PATIENTS WITH CHRONIC HEART FAILURE AND

N T Vatutin, A N Shevelok

    Klinicheskaia Meditsina
    |September 29, 2017
    PubMed

    Insights

    In patients with chronic heart failure, higher aldosterone levels correlate with increased waist circumference and hip ratio, indicating a link between abdominal obesity and hyperaldosteronemia. This finding is crucial for understanding cardiovascular disease prognosis.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Metabolic Disorders

    Background:

    • Blood aldosterone levels are independent predictors of poor prognosis in cardiovascular disorders.
    • The relationship between aldosterone synthesis, activity, and adipose tissue is not well understood in chronic heart failure (CHF).
    • Understanding this link is vital for managing patients with CHF and preserved ejection fraction.

    Purpose of the Study:

    • To investigate the association between blood aldosterone levels and somatometric parameters in patients with CHF.
    • To explore the relationship between aldosterone and body composition in individuals with preserved left ventricular ejection fraction.

    Main Methods:

    • Prospective cohort study of 56 patients (38 men, 18 women) with CHF and preserved ejection fraction (>45%).
    • Measurements included Body Mass Index (BMI), waist circumference (WC), hip circumference (HC), WC/HC ratio, and serum aldosterone levels.
    • Patients were categorized into normal aldosterone and hyperaldosteronemia groups.

    Main Results:

    • Patients with normal aldosterone levels exhibited significantly higher BMI, WC, and WC/HC ratio, with a higher prevalence of abdominal obesity.
    • Aldosterone levels showed positive correlations with WC (r=0.642) and WC/HC ratio (r=0.785), and history of arterial hypertension (r=0.848).
    • No significant correlation was found between aldosterone levels and BMI (r=0.012).

    Conclusions:

    • In CHF patients with preserved ejection fraction, blood aldosterone levels are directly proportional to waist circumference and WC/HC ratio but not BMI.
    • Abdominal obesity is significantly associated with an increased risk of hyperaldosteronemia (relative risk 3.4).
    • These findings highlight the clinical importance of assessing somatometric parameters in relation to aldosterone in CHF management.

    More Related Videos

    Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction09:20

    Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

    Published on: February 13, 2021

    7.1K
    A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs07:09

    A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

    Published on: February 18, 2022

    2.4K

    Related Concept Videos

    Heart Failure II: Pathophysiology01:29

    Heart Failure II: Pathophysiology

    Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
    1.1K
    Heart Failure VI: Adjunct Therapies01:22

    Heart Failure VI: Adjunct Therapies

    Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
    430
    Pathophysiology of Heart Failure01:17

    Pathophysiology of Heart Failure

    Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
    4.1K
    Heart Failure Drugs: Diuretics01:22

    Heart Failure Drugs: Diuretics

    Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
    1.1K
    Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

    Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

    The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
    1.2K
    Heart Failure V: Medical Management01:30

    Heart Failure V: Medical Management

    Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
    392