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Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Related Experiment Video

Updated: Feb 22, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

[Screening for Lung Cancer: Current Status].

Hans Hoffmann¹, Claus Peter Heußel², Martin Eichhorn¹

¹Chirurgie, Thoraxklinik Universitätsklinikum Heidelberg, Deutschland.

Zentralblatt Fur Chirurgie

|September 29, 2017

Summary

This summary is machine-generated.

Lung cancer screening using CT scans shows reduced mortality but carries risks from false positives and invasive follow-ups. Further studies are needed to reassess the risk-benefit ratio.

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Last Updated: Feb 22, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

Area of Science:

Pulmonology
Radiology
Oncology

Background:

Lung cancer screening evidence relies on one trial showing reduced mortality with CT scans.
High false positive rates in CT screening lead to invasive diagnostic procedures and associated risks.

Purpose of the Study:

To evaluate the risk-benefit ratio of lung cancer screening.
To analyze the impact of false positive findings and subsequent invasive procedures.

Main Methods:

Review of existing randomized controlled trial data on CT lung cancer screening.
Analysis of complication rates associated with diagnostic work-ups for false positive findings.

Main Results:

A single trial demonstrated reduced lung cancer mortality in the CT screening group.
Significant risks exist due to high false positive rates and invasive follow-up procedures.

Conclusions:

Current risk-benefit assessment for CT lung cancer screening is unfavorable.
Ongoing European studies (NELSON, LUSI) are expected to provide data for a revised risk-benefit assessment.
Improved work-up algorithms are anticipated to lower false positive and complication rates.