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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
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An Emergence Framework of Carcinogenesis.
Elizabeth A W Sigston1,2,3, Bryan R G Williams3,4
1Department of Otorhinolaryngology, Head & Neck Surgery, Monash Health, Melbourne, VIC, Australia.
Frontiers in Oncology
|September 30, 2017
Summary
A new emergence framework for carcinogenesis integrates existing cancer theories, including somatic mutation theory and tissue organization field theory, using systems biology concepts. This framework aids translational research and understanding of cancer progression.
Area of Science:
- Systems biology
- Carcinogenesis research
- Cancer theory integration
Background:
- Traditional cancer models like somatic mutation theory (SMT) have limitations.
- Alternative theories (e.g., TOFT, evolutionary, inflammatory) exist but are difficult to reconcile.
- Biological systems require a 'systems' approach beyond physicochemical properties.
Purpose of the Study:
- To develop a unified framework for carcinogenesis.
- To integrate diverse cancer theories and concepts.
- To facilitate translational research in oncology.
Main Methods:
- Incorporation of systems, emergence, thermodynamics, and chaos concepts.
- Development of 12 principles for the 'emergence framework of carcinogenesis'.
- Inclusion of non-linear mathematical equations for bioinformatics compatibility.
Main Results:
- A single, integrated framework for carcinogenesis is presented.
- Existing theories are reconciled as compatible mechanisms.
- The framework supports 'benchtop to bedside' and 'bedside to benchtop' translational research.
Conclusions:
- The 'emergence framework of carcinogenesis' unifies current paradigms and evidence.
- It incorporates previously incompatible viewpoints on cancer.
- Applicable to researchers, scientists, and clinicians for cancer research, treatment, and prevention.
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