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Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
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What DKKtates where to metastasize
Wei Zheng1, Jeffrey W Pollard2
1Department of Developmental and Molecular Biology, Albert Einstein College of Medicine and Montefiore Medical Center, New York, New York 10461, USA.
Nature Cell Biology
|September 30, 2017
Abstract:
Cancer cells preferentially metastasize to certain organs. A study in mouse models of breast cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the lung, but enhances tropism to the bone due to the differential regulation of canonical and non-canonical WNT signalling in the two microenvironments.
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