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The effect of azelastine on exercise-induced asthma
H Magnussen1, G Reuss, R Jörres
1Zentrum für Pneumologie und Thoraxchirurgie, Krankenhaus Grosshansdorf, West Germany.
Chest
|May 1, 1988
Summary
Azelastine hydrochloride, an antihistamine, significantly reduced exercise-induced bronchoconstriction in young asthmatic patients. This study shows azelastine
Area of Science:
- Pulmonology
- Allergy and Immunology
- Pharmacology
Background:
- Exercise-induced bronchoconstriction (EIB) is a common condition in asthmatic individuals.
- Cold air provocation is a known trigger for EIB.
Purpose of the Study:
- To evaluate the effect of azelastine hydrochloride on EIB in young asthmatic subjects.
- To assess the bronchodilatory and protective effects of azelastine against cold air-induced bronchoconstriction.
Main Methods:
- A randomized, double-blind, crossover study was conducted.
- Ten young asthmatic subjects underwent exercise challenges.
- Subjects received either azelastine hydrochloride (4.4 mg oral dose) or placebo four hours before challenges on separate days.
Main Results:
- Azelastine hydrochloride demonstrated a small but statistically significant bronchodilation (p < 0.05).
- Azelastine significantly attenuated exercise-induced bronchoconstriction compared to placebo (p < 0.01).
- Placebo had no significant effect on pulmonary function or postexertional airway obstruction.
Conclusions:
- Azelastine hydrochloride effectively reduces exercise-induced bronchoconstriction in young asthmatics.
- The findings suggest azelastine may be a beneficial treatment option for managing EIB in this population.