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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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3DBIONOTES v2.0: a web server for the automatic annotation of macromolecular structures.
Joan Segura1, Ruben Sanchez-Garcia1, Marta Martinez1
1GN7 of the Spanish National Institute for Bioinformatics (INB), Biocomputing Unit, National Center of Biotechnology (CSIC), Instruct Image Processing Center, Madrid 28049, Spain.
Bioinformatics (Oxford, England)
|September 30, 2017
Summary
3DBIONOTES v2.0 automatically annotates biochemical and biomedical information onto macromolecular structural models. This tool aids researchers in evaluating structural consistency for models not yet in public databases.
Area of Science:
- Structural Biology
- Bioinformatics
- Computational Biology
Background:
- Integrating structural data with biochemical and biomedical annotations enhances the understanding of macromolecular complex functions.
- Current annotation tools are limited to structures already deposited in the Protein Data Bank.
Purpose of the Study:
- To introduce 3DBIONOTES v2.0, a web application for automatic annotation of macromolecular structural models.
- To enable consistency assessment between structural models and biological annotations for non-archived structures.
Main Methods:
- Development of a web application for automated annotation.
- Application of the tool to macromolecular structural models from any experimental or computational technique.
Main Results:
- 3DBIONOTES v2.0 provides automatic biochemical and biomedical annotations for macromolecular structures.
- The tool facilitates the analysis of structural models not deposited in public databases.
Conclusions:
- 3DBIONOTES v2.0 enhances the utility of structural models by providing comprehensive annotations.
- The application supports researchers in validating structural models against biological data.
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