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Updated: Feb 22, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Diskogenic Reactivation of Herpes Zoster
Rana S Dhillon1, Paul D Smith2
1Department of Neurosurgery, St. Vincent's Hospital, Melbourne, Australia; Centre for Clinical Neuroscience and Neurological Research, Melbourne, Australia.
Abstract:
Varicella zoster virus remains dormant in the dorsal root ganglia after childhood exposure to chickenpox. Its reactivation results in herpes zoster, otherwise known as shingles, which is a painful vesicular rash in a dermatomal distribution. We present a case of foraminal disk extrusion that resulted in radicular pain in a dermatomal distribution. The resultant inflammatory response around the dorsal root ganglion triggered an episode of shingles, which elegantly highlights the pathophysiology of this condition at a gross anatomic level.
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