Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c...

Area of Science:

• * Nutritional Science
• * Gastroenterology
• * Oncology

Background:

• * Colitis-associated colon cancer (CAC) poses a significant health challenge.
• * Dietary components, such as peptides from common beans, are being explored for chemopreventive properties.
• * The non-digestible fraction of common bean cv. Azufrado Higuera (AH) contains bioactive peptides with potential health benefits.

Purpose of the Study:

• * To evaluate the antineoplastic potential of a peptide extract from common bean cv. Azufrado Higuera (AH) and its main peptide GLTSK.
• * To assess the efficacy of AH and GLTSK in preventing colitis-associated colon carcinogenesis in a mouse model.

Main Methods:

• * A mouse model of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated colon carcinogenesis was utilized.
• * Experimental groups included a healthy control (C-), induced control (C+), AH treatment group, and GLTSK treatment group.
• * AH and GLTSK were administered at a dose of 50 mg/kg-bw.

Main Results:

• * Administration of AH and GLTSK significantly decreased the disease activity index (DAI) compared to the induced control group (p < 0.05).
• * The AH group showed a significant reduction in the number of evident neoplasms compared to the induced control group.
• * AH and GLTSK treatments demonstrated a protective effect against CAC development.

Conclusions:

• * Peptides derived from common bean cv. Azufrado Higuera exhibit significant antineoplastic potential.
• * AH and GLTSK may serve as promising agents for the prevention of colitis-associated colon cancer.
• * Further research into the mechanisms of action of these bean peptides is warranted.