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Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
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Updated: Feb 22, 2026

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
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Phenylalanine Increases Membrane Permeability.

Russell Perkins1, Veronica Vaida1

  • 1University of Colorado Boulder , 215 UCB, Boulder, Colorado 80309, United States.

Journal of the American Chemical Society
|October 3, 2017
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Summary
This summary is machine-generated.

The amino acid phenylalanine increases biological membrane permeability. This finding may explain harmful symptoms in phenylketonuria, a genetic disorder causing high phenylalanine levels.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Neuroscience

Background:

  • Biological membranes regulate cellular processes by controlling chemical component distribution.
  • Membrane permeability is vital for metabolism (electron transport) and nerve cell function (signal propagation).

Purpose of the Study:

  • To investigate the effect of the amino acid phenylalanine on biological membrane permeability.
  • To explore the potential link between phenylalanine-induced permeability changes and phenylketonuria symptoms.

Main Methods:

  • The study likely involved experiments to measure membrane permeability in the presence of phenylalanine.
  • Analysis of phenylalanine's impact on membrane properties.

Main Results:

  • Phenylalanine was found to increase biological membrane permeability.
  • This increase is a potential mechanism for adverse effects observed in high phenylalanine conditions.

Conclusions:

  • Elevated phenylalanine levels can alter membrane function by increasing permeability.
  • This mechanism offers insight into the pathophysiology of phenylketonuria.