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Updated: Feb 22, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Aspirin and Nonsteroidal Antiinflammatory Drugs Hypersensitivity and Management
Brian Modena1, Andrew A White1, Katharine M Woessner1
1Division of Allergy, Asthma and Immunology, Scripps Clinic, 3811 Valley Centre Drive, S99, San Diego, CA 92130, USA.
Abstract:
Aspirin and nonsteroidal antiinflammatory drugs (NSAIDs) are widely used in the United States and throughout the world for a variety of indications. Several unique hypersensitivity syndromes exist to this class of medications, making them one of the common reasons for consultation to the allergist. The lack of any laboratory-based diagnostic studies to assist in identifying the culprits in these reactions make evaluation of aspirin and NSAID hypersensitivity challenging. Identifying patients appropriate for oral challenge and/or desensitization protocols is the standard pragmatic approach to this issue when it arises.
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