Related Experiment Video
Updated: Feb 22, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
Severe Delayed Drug Reactions: Role of Genetics and Viral Infections
Rebecca Pavlos1, Katie D White2, Celestine Wanjalla2
1Institute for Immunology and Infectious Diseases, Murdoch University, 6150 Murdoch, Western Australia, Australia.
Abstract:
Adverse drug reactions (ADRs) are a significant source of patient morbidity and mortality and represent a major burden to health care systems and drug development. Up to 50% of such reactions are preventable. Although many ADRs can be predicted based on the on-target pharmacologic activity, ADRs arising from drug interactions with off-target receptors are recognized. Off-target ADRs include the immune-mediated ADRs (IM-ADRs) and pharmacologic drug effects. In this review, we discuss what is known about the immunogenetics and pathogenesis of IM-ADRs and the hypothesized role of heterologous immunity in the development of IM-ADRs.
Related Concept Videos
Drug toxicity: Idiosyncratic Reactions
Drug Toxicity: Risk factors
Pharmacokinetics: Drug–Food and Drug–Viral Interactions
Drug Toxicity: Allergic Reactions
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Allergic Drug Reactions

