Related Experiment Video

Updated: Feb 22, 2026

Decellularization and Recellularization Methodology for Human Saphenous Veins
11:35

Decellularization and Recellularization Methodology for Human Saphenous Veins

Published on: July 27, 2018

14.8K

Platelet-derived growth factor-C and -D in the cardiovascular system and diseases

Chunsik Lee1, Xuri Li1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, PR China.

Molecular Aspects of Medicine
|October 3, 2017
PubMed

Insights

Platelet-derived growth factors (PDGFs), particularly PDGF-C and PDGF-D, are vital for cardiovascular development and function. Understanding their roles offers new therapeutic avenues for cardiovascular diseases.

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Molecular Medicine

Background:

  • The cardiovascular system is essential for organ development and function.
  • Platelet-derived growth factors (PDGFs) and their receptors are key regulators of cardiovascular homeostasis.
  • PDGF-C and PDGF-D are recently identified PDGF family members with demonstrated cardiovascular roles.

Purpose of the Study:

  • To elucidate the critical functions of PDGF-C and PDGF-D in the cardiovascular system.
  • To explore the signaling pathways regulated by PDGF-C and PDGF-D.
  • To identify potential therapeutic targets for cardiovascular diseases based on PDGF signaling.

Main Methods:

  • Review of existing literature on PDGFs in cardiovascular research.
  • Analysis of studies demonstrating the angiogenic and survival roles of PDGF-C and PDGF-D.
  • Investigation of signaling pathways associated with PDGF-C and PDGF-D.

Main Results:

  • PDGF-C and PDGF-D act as crucial angiogenic and survival factors in the cardiovascular system.
  • These factors play significant roles in cardiovascular development and maintenance.
  • Specific signaling pathways modulated by PDGF-C and PDGF-D have been identified.

Conclusions:

  • PDGF-C and PDGF-D are important regulators of cardiovascular function.
  • Further understanding of PDGF-C and PDGF-D signaling can advance basic cardiovascular research.
  • Targeting PDGF-C and PDGF-D pathways may offer novel therapeutic strategies for cardiovascular diseases.

Keywords:
CardiogenesisCardiovascular diseasePDGF-CPDGF-DPlatelet-derived growth factor (PDGF)Vascular development

More Related Videos

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

10.2K
Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

9.9K

Related Concept Videos

Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
4.0K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.8K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
9.5K
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.9K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.2K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
630