Related Experiment Video
Updated: Feb 22, 2026

Establishing a Competing Risk Regression Nomogram Model for Survival Data
Published on: October 23, 2020
Single-Arm Phase II Survival Trial Design Under the Proportional Hazards Model
1Department of Biostatistics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Abstract:
For designing single-arm phase II trials with time-to-event endpoints, a sample size formula is derived for the modified one-sample log-rank test under the proportional hazards model. The derived formula enables new methods for designing trials that allow a flexible choice of the underlying survival distribution. Simulation results showed that the proposed formula provides an accurate estimation of sample size. The sample size calculation has been implemented in an R function for the purpose of trial design.
Related Concept Videos
Comparing the Survival Analysis of Two or More Groups
Assumptions of Survival Analysis
Introduction To Survival Analysis
The primary goal of survival analysis is to estimate survival time—the time...
Cancer Survival Analysis
Actuarial Approach
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Kaplan-Meier Approach

