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Cancer and Aging - the Inflammatory Connection.
Adar Zinger1, William C Cho2, Arie Ben-Yehuda1
11Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Aging and Disease
|October 3, 2017
Summary
Aging accelerates cancer development, despite opposing hallmarks. This review explores molecular pathways linking aging and cancer, focusing on inflammation and potential therapeutic targets.
Area of Science:
- Gerontology and Oncology
- Molecular Biology
- Inflammation Research
Background:
- Aging and cancer are strongly correlated, with aging being a primary risk factor for cancer.
- Cellular processes like DNA damage responses and senescence contribute to aging but also suppress tumors.
- Aging exhibits tissue degeneration, contrasting with cancer's sustained cellular proliferation.
Purpose of the Study:
- To review molecular and cellular pathways underlying age-related cancer.
- To examine the inflammatory perspective connecting aging and cancer.
- To identify potential molecular targets for intervention.
Main Methods:
- Literature review of molecular and cellular pathways.
- Analysis of the role of inflammation in aging and cancer.
- Exploration of potential therapeutic targets.
Main Results:
- Aging processes contribute to a pro-tumorigenic state.
- Inflammation is a key linking mechanism between aging and cancer.
- Specific molecular pathways and targets are implicated in age-related cancer development.
Conclusions:
- Understanding the interplay between aging and cancer, particularly inflammation, is crucial.
- Targeting shared molecular pathways may offer novel therapeutic strategies for both aging and cancer.
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