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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Italian prescribing patterns in obsessive-compulsive disorder.

Donatella Marazziti1, Umberto Albert2, Bernardo Dell'Osso3,4

  • 1Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Italy.

Human Psychopharmacology
|October 3, 2017
PubMed
Summary

Psychopharmacological prescribing for obsessive-compulsive disorder (OCD) shows variability across specialized Italian centers. While most patients receive medication, the types and frequency of drugs like SSRIs and TCAs differ, suggesting influences beyond guidelines.

Keywords:
obsessive-compulsive disorderpsychopharmacological treatmentsspecialized OCD centerstreatment guidelines

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Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Obsessive-compulsive disorder (OCD) is a debilitating mental health condition requiring effective psychopharmacological treatment.
  • Understanding current prescribing patterns is crucial for optimizing patient care and adherence to evidence-based guidelines.

Purpose of the Study:

  • To investigate and compare psychopharmacological prescribing practices for OCD patients across four specialized Italian centers.
  • To assess adherence to national and international treatment guidelines.

Main Methods:

  • A large sample of 1815 OCD patients from four Italian specialized centers participated.
  • Data on psychotropic medication use was collected via a specific data sheet questionnaire.
  • Statistical analyses were performed using SPSS to compare prescribing patterns.

Main Results:

  • Nearly all patients in Milan, Pisa, and Rome received psychotropic medications, compared to 59.9% in Turin.
  • Selective serotonin reuptuptake inhibitors (SSRIs) were the most common drugs (49.0%-71.5%).
  • Variations in the use of clomipramine, other TCAs, second-generation antipsychotics, and mood stabilizers were observed across centers.

Conclusions:

  • Italian specialized centers largely follow OCD treatment guidelines, but significant prescribing variability exists.
  • Differences in prescribing may stem from educational backgrounds, therapeutic strategies, and patient-specific factors like severity and comorbidity.