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Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Feb 22, 2026

Production of Human CRISPR-Engineered CAR-T Cells

Production of Human CRISPR-Engineered CAR-T Cells

Published on: March 15, 2021

Gene editing in T cell therapy.

Yongping Zhang¹, Wei Mu², Haoyi Wang²

¹State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100190, China; Department of Hematology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University, Beijing 100049, China.

Journal of Genetics and Genomics = Yi Chuan Xue Bao

|October 3, 2017

Summary

This summary is machine-generated.

Gene editing enhances T cell therapies for cancer, autoimmunity, and infections. This review explores gene editing applications in antiviral strategies and cancer immunotherapies, discussing challenges and future directions.

Keywords:

CRISPR-Cas9 Gene editing T cells

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Last Updated: Feb 22, 2026

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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

Area of Science:

Immunology
Gene Therapy
Oncology

Background:

Adoptive transfer of engineered T cells shows promise for treating cancer, autoimmunity, and infectious diseases.
Gene editing technologies offer significant potential for advancing T cell therapies.

Purpose of the Study:

To review the applications of gene editing in T cell therapies.
To focus on gene editing for antiviral strategies and cancer immunotherapies.
To discuss challenges and future prospects in the field.

Main Methods:

Literature review of gene editing applications in T cell therapy.
Focus on studies related to antiviral and cancer immunotherapy applications.
Analysis of current challenges and future directions.

Main Results:

Gene editing is being applied to enhance T cell functions for therapeutic purposes.
Specific applications include improving antiviral responses and cancer immunotherapies.
The review highlights the potential and ongoing development in the field.

Conclusions:

Gene editing is a powerful tool for improving T cell-based therapies.
Further research and development are needed to overcome existing challenges.
The future prospects for gene-edited T cell therapies are significant.