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Biological evaluation of silver nanoparticles incorporated into chitosan-based membranes
Jinlong Shao1, Na Yu2,3, Eva Kolwijck4
1Department of Biomaterials, Radboud University Medical Centre, 6500 HB, Nijmegen, The Netherlands.
Aim:
To evaluate the antibacterial potential and biological performance of silver nanoparticles in chitosan-based membranes.
Materials & Methods:
Electrospun chitosan/poly(ethylene oxide) membranes with different amounts of silver nanoparticles were evaluated for antibacterial properties and cytotoxicity in vitro and for tissue response in a rabbit subcutaneous model.
Results:
The nanoparticles displayed dose-dependent antibacterial properties against Porphyromonas gingivalis and Fusobacterium nucleatum, without showing noticeable cytotoxicity. The membranes with silver nanoparticles evoked a similar inflammatory response compared with the membranes without silver nanoparticles.
Conclusion:
The antibacterial effect, combined with the findings on cyto- and biocompatibility warrants further investigation to the usefulness of chitosan/poly(ethylene oxide) membranes with silver nanoparticles, for clinical applications like guided tissue regeneration.
