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Meropenem Induced Hypokalemia

T V Anuhya1, Raviraj Acharya2, Sharath MadhyasthaA2

  • 1Postgraduate, Department of Pharmacology, KMC, Manipal University, Udupi, Karnataka, India.

Journal of Clinical and Diagnostic Research : JCDR
|October 4, 2017
PubMed

Insights

Meropenam, a broad-spectrum antibiotic, can cause hypokalemia (low potassium). This rare adverse effect requires physician awareness, especially in patients with cellulitis or urinary tract infections.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Meropenam is a carbapenem antibiotic used for severe bacterial infections.
  • Commonly reported side effects include gastrointestinal issues and hypersensitivity.
  • Its potential to induce electrolyte disturbances is less documented.

Observation:

  • Two hospitalized patients developed hypokalemia during meropenam treatment.
  • Case 1: Meropenam prescribed for cellulitis.
  • Case 2: Meropenam prescribed for urinary tract infection.

Findings:

  • Meropenam administration was associated with the development of hypokalemia in both cases.
  • Hypokalemia presents with a range of symptoms, from muscle weakness to respiratory failure.
  • This highlights a potential, under-recognized adverse drug reaction.

Implications:

  • Physicians should consider meropenam-induced hypokalemia in patients presenting with compatible symptoms.
  • Monitoring potassium levels may be warranted in certain patient populations receiving meropenam.
  • Increased awareness can prevent delayed diagnosis and management of this adverse effect.
Keywords:
Antibacterial agentsBeta-lactam antibioticsHypokalemiaInfections

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