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Meropenem Induced Hypokalemia
T V Anuhya1, Raviraj Acharya2, Sharath MadhyasthaA2
1Postgraduate, Department of Pharmacology, KMC, Manipal University, Udupi, Karnataka, India.
Journal of Clinical and Diagnostic Research : JCDR
|October 4, 2017
Summary
Meropenam, a broad-spectrum antibiotic, can cause hypokalemia (low potassium). This rare adverse effect requires physician awareness, especially in patients with cellulitis or urinary tract infections.
Area of Science:
- Pharmacology
- Infectious Diseases
- Clinical Medicine
Background:
- Meropenam is a carbapenem antibiotic used for severe bacterial infections.
- Commonly reported side effects include gastrointestinal issues and hypersensitivity.
- Its potential to induce electrolyte disturbances is less documented.
Observation:
- Two hospitalized patients developed hypokalemia during meropenam treatment.
- Case 1: Meropenam prescribed for cellulitis.
- Case 2: Meropenam prescribed for urinary tract infection.
Findings:
- Meropenam administration was associated with the development of hypokalemia in both cases.
- Hypokalemia presents with a range of symptoms, from muscle weakness to respiratory failure.
- This highlights a potential, under-recognized adverse drug reaction.
Implications:
- Physicians should consider meropenam-induced hypokalemia in patients presenting with compatible symptoms.
- Monitoring potassium levels may be warranted in certain patient populations receiving meropenam.
- Increased awareness can prevent delayed diagnosis and management of this adverse effect.
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