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Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

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Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
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The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
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Related Experiment Video

Updated: Feb 21, 2026

Electrophysiological Measurement of Noxious-evoked Brain Activity in Neonates Using a Flat-tip Probe Coupled to Electroencephalography
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Measuring Harm in Hospitalized Children via a Trigger Tool.

Lya M Stroupe1, Kamakshya P Patra2, Zheng Dai3

  • 1WVU Medicine Children's Hospital, Morgantown, United States.

Journal of Pediatric Nursing
|October 4, 2017
PubMed
Summary

The Global Assessment of Pediatric Patient Safety (GAPPS) tool identified four times more adverse events in hospitalized children than the hospital incident reporting system. This tool enhances patient safety by improving the detection of medical errors.

Keywords:
Adverse eventsGlobal Trigger ToolInpatient harmMedical errorsPatient safetyPediatric Global Trigger Tool

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Area of Science:

  • Pediatric Patient Safety
  • Healthcare Quality Improvement
  • Medical Error Detection

Background:

  • Medical errors cause significant annual deaths in US hospitals, with existing detection methods being inconsistent.
  • Hospitalized pediatric patients face a high risk of adverse events, ranging from 1% to 11% of admissions.

Purpose of the Study:

  • To evaluate the Global Assessment of Pediatric Patient Safety (GAPPS) tool for detecting adverse events in a pediatric inpatient setting.
  • To compare the efficacy of the GAPPS tool against internal incident reporting systems.

Main Methods:

  • A retrospective chart review of 100 pediatric patients was conducted using the GAPPS tool by nurse reviewers.
  • Adverse events detected by GAPPS were validated by physicians, who also assessed harm severity and preventability.
  • The number of adverse events identified by GAPPS was compared to the hospital's internal incident reports.

Main Results:

  • The GAPPS tool detected 20 adverse events in 100 reviewed charts, a detection rate of 4.87% per 411 patient-days.
  • The hospital's internal incident reporting system captured only 1.22% of adverse events during the same period.

Conclusions:

  • The GAPPS tool is significantly more effective, detecting four times as many adverse events as the current hospital incident reporting system.
  • Implementing the GAPPS tool in pediatric hospitals can substantially improve the identification of adverse events and patient harm.
  • Findings suggest broader applicability of the GAPPS tool in enhancing patient safety across children's hospitals.