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Bone Age Assessments by Quantitative Ultrasound (SonicBone) and Hand X-ray Based Methods are Comparable
Marianna Rachmiel1,2, Larisa Naugolni1, Kineret Mazor-Aronovitch2,3
1Pediatric Endocrinology Clinic, Assaf Harofeh Medical Center, Zerifin Israel.
Background:
Bone maturation is currently assessed by subjective and automated radiography.
Objectives:
To evaluate the concordance and reproducibility of a quantitative ultrasound (QUS) based device versus X-ray based methods.
Methods:
The study population comprised 150 children, 76 males, 4-17 years of age. X-ray scans were evaluated according to wrist, carpal and phalanx areas for bone age. QUS was performed by the the BAUS™ device (SonicBone, Rishon Lezion, Israel), using speed-of-sound (SOS) and distance attenuation factor (ATN) in similar areas. Data from 100 subjects were used to establish the device conversion equation, and 50 measurements were assigned to assess inter-modality agreement.
Results:
BAUS showed high repeatability performance, 0.73% relative standard deviation for SOS and 3.5% for ATN. R2 for the conversion equation, including gender, SOS, and ATN, was 0.80 for all methods (P < 0.001). There was no significant bias in bone age assessments.
Conclusions:
Bone age assessment by SonicBone is comparable to the assessment by X-ray based methods.
