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Updated: Feb 21, 2026

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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
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Enzymatic Generation of Highly Anticoagulant Bovine Intestinal Heparin
1The Pharmaceutical Research Institute, Albany College of Pharmacy , Rensselaer, New York 12144, United States.
Journal of Medicinal Chemistry
|October 4, 2017
Abstract:
Unlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1, -3, and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin.

