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Size effect on oral absorption in polymer-functionalized mesoporous carbon nanoparticles
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, PR China.
Journal of Colloid and Interface Science
|October 4, 2017
Summary
Particle size of polymer-functionalized mesoporous carbon (MPP) nanoparticles significantly impacts oral drug absorption. Intermediate-sized MPP nanoparticles show promise as effective carriers for water-insoluble drugs like fenofibrate, enhancing bioavailability.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Oral drug delivery faces challenges with water-insoluble drugs.
- Mesoporous carbon nanoparticles (MCNs) offer potential for drug delivery applications.
- Surface functionalization can enhance nanoparticle properties for drug absorption.
Purpose of the Study:
- To investigate the effect of particle size of polymer-functionalized mesoporous carbon (MPP) nanoparticles on oral absorption of fenofibrate (Fen).
- To evaluate MPP nanoparticles as carriers for improving the bioavailability of water-insoluble drugs.
- To guide the rational design of nanoparticle-based oral drug delivery systems.
Main Methods:
- MPP nanoparticles with varying particle sizes were synthesized by functionalizing MCNs with branched polyethyleneimine (PEI) and polyacrylic acid (PAA).
- Fenofibrate (Fen) was loaded into MPP nanoparticles.
- PEI-functionalized carbon quantum dots (PCA) and 125I were used for in vivo tracing.
- In vitro dissolution and in vivo oral absorption studies were conducted.
Main Results:
- MPP nanoparticles significantly improved the dissolution rate and oral bioavailability of Fen.
- Nanoparticle size critically influenced Fen oral absorption, with intermediate sizes being optimal.
- The developed MPP nanoparticles demonstrated safety and efficient excretion in vivo.
Conclusions:
- MPP nanoparticles are effective carriers for enhancing the oral delivery of water-insoluble drugs.
- Optimizing nanoparticle size is crucial for maximizing oral absorption and bioavailability.
- This study provides valuable insights for designing advanced oral drug delivery systems using functionalized nanoparticles.
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