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Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
Published on: April 26, 2024
Emerging Therapeutic Strategies in Breast Cancer
Kayla Cox1, Brandon Alford1, Hatem Soliman1
1From the Lake Erie College of Osteopathic Medicine, Bradenton, Florida, the University of South Florida College of Medicine, Tampa, and the H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Abstract:
The field of medical oncology is experiencing a period of rapid evolution owing to advances in the fields of genomics, tumor biology, and immunology. These disciplines have provided valuable insights into the heterogeneity between breast tumors, key oncogenic drivers, and the role of the immune system in the natural history of breast cancer. This knowledge is translating into many novel therapeutic strategies using personalized medicines, targeted drug delivery systems, and immunomodulatory agents in the treatment of both the early and metastatic stages of the disease. This review article attempts to cover the major developments in experimental therapeutics and how they relate to our understanding of breast cancer and its various biologic subtypes.
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