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Related Experiment Video

Updated: Feb 21, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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Selective internal radiation therapy for liver tumours.

Francis X Sundram1, John R Buscombe2

  • 1University Hospital Southampton NHS Foundation Trust, Southampton, UK francis.sundram@uhs.nhs.uk.

Clinical Medicine (London, England)
|October 5, 2017
PubMed
Summary

Selective internal radiation therapy (SIRT) offers a promising treatment for unresectable liver tumors, delivering targeted radiation to cancer cells. Clinical trials show it prolongs liver progression-free survival in patients who have undergone chemotherapy.

Keywords:
InternalSIRTlivermalignancyradiationselectivetherapy

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Interventional Radiology

Background:

  • Primary and secondary liver malignancies frequently occur and have poor prognoses.
  • Surgical resection is the preferred treatment, but many patients present with unresectable disease.
  • Liver-directed therapies are crucial for managing unresectable liver tumors.

Purpose of the Study:

  • To evaluate the efficacy and safety of Selective Internal Radiation Therapy (SIRT) for liver malignancies.
  • To highlight SIRT as a multidisciplinary approach for liver cancer treatment.
  • To discuss the role of SIRT in patients with unresectable liver disease.

Main Methods:

  • SIRT involves delivering high doses of localized internal radiation directly to liver tumor tissues.
  • This technique selectively targets malignant cells while sparing adjacent normal liver parenchyma.
  • The treatment is a collaborative effort involving nuclear medicine, interventional radiology, and oncology specialists.

Main Results:

  • Clinical trials indicate that SIRT can prolong liver progression-free survival in patients who have progressed following chemotherapy.
  • Side effects associated with SIRT are generally minimal.
  • Post-treatment radiation protection measures are straightforward.

Conclusions:

  • SIRT is an approved and available treatment option for specific liver malignancies in England.
  • It represents a unique and personalized treatment approach for liver tumors.
  • SIRT offers a valuable therapeutic option for patients with unresectable liver disease.