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Thrombectomy in Acute Stroke With Tandem Occlusions From Dissection Versus Atherosclerotic Cause
Benjamin Gory1, Michel Piotin2, Diogo C Haussen2
1From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Santé Publique: Épidémiologie et Qualité des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department of Neurology, Emory University/Grady Memorial Hospital, Atlanta, GA (R.G.N., D.C.H.); Department of Diagnostic and Interventional Neuroradiology, Klinikum Bremen-Mitte/Bremen-Ost, Deutschland (P.P., M.B.); Department of Neurosurgery, State University of New York, Buffalo (A.H.S.); Department of Neurology, Stroke Center, Foch Hospital, Suresnes, France (B.L.); Department of Neuroradiology, University Hospital of Munich, Germany (F.D.); Department of Neuroradiology, University Hospital of Toulouse, France (C.C.); Department of Neuroradiology, Paracelsus Medical University Salzburg, Austria (M.K.); Department of Interventional Neuroradiology, Careggi University Hospital, Florence, Italy (S.M.); Department of Neurology, Hospital Vall D'Hebron, Barcelona, Spain (M.R.); Department of Neuroradiology, University Medical Center Göttingen, Germany (D.B.); Department of Neurosurgery, Medical University of South Carolina, Charleston (A.M.S.). benjagory@gmail.com.
Background And Purpose:
Tandem steno-occlusive lesions were poorly represented in randomized trials and represent a major challenge for endovascular thrombectomy in acute anterior circulation strokes. The impact of the cervical carotid lesion cause (ie, atherosclerotic versus dissection) on outcome of tandem patients endovascularly treated remains to be assessed.
Methods:
We retrospectively analyzed individual data of prospectively collected consecutive tandem patients treated with endovascular thrombectomy. The primary outcome was favorable outcome at 90 days (modified Rankin Scale score of 0-2). Secondary efficacy outcomes included successful reperfusion (modified Thrombolysis in Cerebrovascular Infarction scores of 2b-3), time to reperfusion, and safety outcomes encompassed procedural complications, symptomatic intracerebral hemorrhage, and 90-day mortality.
Results:
Among the 295 included patients, 65 had cervical carotid dissection and 230 had cervical carotid atherosclerotic cause. The rate of favorable outcome was 56.3% in the dissection group versus 47.6% in the atherosclerotic arm (center-, age-, and admission National Institutes of Health Stroke Scale-adjusted odds ratio, 1.08; 95% confidence interval, 0.50-2.30; P=0.85). No significant differences were observed in secondary outcomes. The rates of successful reperfusion, symptomatic intracerebral hemorrhage, and 90-day mortality were 78.5% versus 74.5% (P=0.13), 4.6% versus 5.2% (P=1.0), and 7.8% versus 15.3% (P=0.94) in the dissection versus atherosclerotic groups, respectively. The median procedural time was 76 minutes (interquartile range, 52-95 minutes) in the dissection group and 67 minutes (interquartile range, 45-98 minutes) in the atherosclerotic group (P=0.24).
Conclusions:
We found no differences in the outcomes of patients with anterior circulation tandem atherosclerotic and dissection lesions treated with endovascular thrombectomy. Further studies are warranted.
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