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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
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Liver transplantation in Asia: Problems and practice.

S T Fan1

  • 1Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong.

Journal of Gastroenterology and Hepatology
|October 5, 2017
PubMed
Summary
This summary is machine-generated.

Living-related liver transplantation has advanced in Asia, overcoming organ shortages and hepatitis B infections. Lamivudine effectively prevents graft reinfection, improving patient survival rates in liver transplant recipients.

Keywords:
Asiahepatitis Bliver transplantation

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Area of Science:

  • Hepatology
  • Transplant Surgery
  • Infectious Diseases

Background:

  • Liver transplantation in Asia faces challenges including organ donation reluctance, financial constraints, and high hepatitis B prevalence.
  • Hepatitis B significantly reduces available cadaveric organs, necessitating alternative strategies for liver transplantation.
  • Living-related liver transplantation, initially for pediatric patients, has become crucial in addressing organ scarcity in Asia.

Purpose of the Study:

  • To evaluate the progress and challenges of liver transplantation in Asia.
  • To assess the efficacy of living-related liver transplantation in overcoming organ shortages.
  • To determine the effectiveness of lamivudine in preventing hepatitis B reinfection post-transplantation.

Main Methods:

  • Establishment and expansion of living-related liver transplantation for pediatric and adult patients.
  • Peri-operative use of lamivudine to combat hepatitis B viral infection in liver transplant recipients.
  • Monitoring of hepatitis B surface antigen (HBsAg) and hepatitis B virus DNA in patients receiving lamivudine.

Main Results:

  • Over 785 liver transplantations performed in major Asian centers with an 80% patient survival rate.
  • Lamivudine demonstrated high efficacy in preventing graft reinfection; HBsAg disappeared in 11 of 15 patients.
  • Lamivudine proved cheaper and more convenient than hepatitis B immunoglobulin for graft protection.

Conclusions:

  • Despite obstacles, significant progress in liver transplantation is evident in Asia.
  • Living-related liver transplantation is a viable solution for organ shortages.
  • Lamivudine is an effective and cost-efficient strategy for managing hepatitis B in liver transplant patients.