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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
Published on: October 25, 2024
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The Burgeoning World of Immunometabolites: Th17 Cells Take Center Stage
Glenn R Bantug1, Christoph Hess1
1Immunobiology, Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland.
Cell Metabolism
|October 6, 2017
Abstract:
Dysregulation of the Th17/Treg balance is a key driver of autoimmunity. A new study by Xu et al. (2017) has revealed that small-molecule inhibition of 2-hydroxyglutarate synthesis skews Th17 differentiation to the Treg lineage, which is protective against autoimmune inflammation.
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