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Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling

Rebeca Caires1, Francisco J Sierra-Valdez1, Jonathan R M Millet1

  • 1Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Cell Reports
|October 6, 2017
PubMed
Summary

Omega-3 polyunsaturated fatty acids (PUFAs) enhance TRPV4 channel activity, crucial for blood vessel relaxation. This discovery suggests ω-3 PUFA-like compounds could be potential antihypertensive agents targeting TRPV4.

Keywords:
17,18-epoxyeicosatetraenoic acidCaenorhabditis elegansTRP channelsTRPV4atomic force microscopyeicosapentaenoic acidendothelial cellsfatty acidsneuronspolyunsaturated fatty acids

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