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Effect of the Inclusion Nanocomplex Formed of Titanium Tetrafluoride and β-Cyclodextrin on Enamel Remineralization
Thiago Isidro Vieira1, Camila Nassur1, Adílis Kalina Alexandria1
1Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Objective:
Titanium tetrafluoride (TiF4) is a topical agent used in the control of dental caries; however, it is highly acidic. To minimize this effect, cyclodextrins (CDs) are used. This study evaluated the in vitro potential of TiF4 and β-CD on remineralization.
Methods:
Forty bovine enamel blocks were selected by microhardness and randomly assigned to four groups (n = 10 per group): control (distilled and deionized water), 1% β-CD solution, 1% TiF4 solution, and TiF4: β-CD solution. The blocks were subjected to a pH cycling regimen for 8 days. After that, samples were evaluated by cross-sectional microhardness (CSMH), scanning electron microscopy (SEM), and energy dispersive spectrometry (EDS). Data were assessed for normality and analyzed using ANOVA and Tukey's tests (α = 0.05).
Results:
Regarding CSMH, TiF4: β-CD was statistically superior to the control (P = 0.033), β-CD (P = 0.022), and TiF4 (P = 0.006). SEM photomicrography revealed the titanium dioxide coating on slabs treated with TiF4 and TiF4: β-CD. EDS assessment demonstrated the presence of titanium on the surface of slabs treated with TiF4 and TiF4: β-CD.
Conclusion:
The solution containing the inclusion nanocomplex formed of TiF4 and β-CD was able to reharden the enamel subsurface.
