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BANCR: a cancer-related long non-coding RNA
Xin Yu1, Heyi Zheng1, Matthew Tv Chan2
1Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing 100042, China.
American Journal of Cancer Research
|October 6, 2017
Summary
Long non-coding RNAs (lncRNAs) play roles in cell processes and cancer. BRAF-activated non-coding RNA (BANCR) is deregulated in various cancers, acting as either an oncogene or tumor suppressor.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are key regulators in biological processes.
- Emerging evidence implicates lncRNAs in cancer development, acting as oncogenes or tumor suppressors.
- BRAF-activated non-coding RNA (BANCR) was initially identified as an oncogene in melanoma.
Purpose of the Study:
- To review the functional roles of BANCR in tumor development.
- To elucidate the molecular mechanisms of BANCR in various cancers.
- To summarize the tissue-specific deregulation of BANCR in human cancers.
Main Methods:
- Literature review of studies on BANCR and cancer.
- Compilation of evidence on BANCR's functions and mechanisms.
- Analysis of BANCR deregulation across different cancer types.
Main Results:
- BANCR is frequently deregulated in lung, gastric, colorectal, thyroid cancers, and osteosarcoma.
- BANCR's role as an oncogene or tumor suppressor is tissue-specific.
- Evidence suggests diverse molecular mechanisms underlying BANCR's functions in tumorigenesis.
Conclusions:
- BANCR is a significant player in human cancer development.
- Understanding BANCR's dual role is crucial for cancer research.
- Further investigation into BANCR's mechanisms can reveal therapeutic targets.
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