[Total antioxidant status of blood in various types of ischemic stroke]
Yu I Kravtsov1, E Yu Kravtsova1, S I Selezneva1
1Vagner Perm State Medical University of the Ministry of Healthcare of the Russian Federation, Perm, Russia.
Insights
Reduced antioxidant status (AOS) in blood serum is linked to all forms of ischemic stroke (IS). This finding highlights an imbalance between prooxidative and antioxidative systems during IS development.
Area of Science:
- Biochemistry
- Neurology
- Clinical Medicine
Background:
- Ischemic stroke (IS) is a major cause of disability and mortality worldwide.
- Understanding the biochemical markers associated with IS pathogenesis is crucial for developing effective treatments.
- Antioxidant status (AOS) plays a vital role in cellular protection against oxidative stress, a known factor in IS.
Purpose of the Study:
- To investigate the antioxidant status (AOS) in the blood serum of patients during the acute phase of various pathogenic forms of ischemic stroke (IS).
- To determine if AOS levels differ among different etiological subtypes of IS.
- To explore the relationship between AOS and the development of IS.
Main Methods:
- A study group of 99 patients with atherothrombotic (n=74), cardioembolic (n=15), and lacunar (n=10) ischemic stroke.
- A control group of 15 healthy individuals.
- Total antioxidant status (TAS) in blood serum was measured using the 'General antioxidatic status - Novo' test system within 1-2 days of disease onset.
Main Results:
- Patients with IS exhibited significantly lower AOS (1.15±0.41 mmol/L) compared to the control group (1.69±0.17 mmol/L) (p=0.000001).
- Reduced AOS was observed across all pathogenic forms of IS, including atherothrombotic, cardioembolic, and lacunar types, with no significant difference between these subtypes.
- AOS levels did not significantly differ between men and women and were independent of age and lesion location.
Conclusions:
- A reduced AOS in blood serum is indicative of an imbalance between prooxidative and antioxidative systems in the formation of all pathogenic forms of IS.
- The findings suggest that oxidative stress is a common underlying mechanism in the pathogenesis of various IS types.
- Monitoring AOS could potentially serve as a biomarker for IS and inform therapeutic strategies targeting oxidative stress.
Aim:
To study the antioxidant status (AOS) of blood serum of patients in the acute period in patients with a variety of pathogenic forms of ischemic stroke (IS).
Material And Methods:
A total of 99 patients (study group) with different types of ischemic stroke (IS): with atherothrombotic variant (n=74) IS, with cardioembolic (n=15) with lacunar type (n=10). The control group consisted of 15 persons. Total antioxidant status (TAS) in the blood serum was examined by the test system 'General antioxidatic status - Novo' ('Vector-Best', Russia) for 1-2 days from the onset of the disease.
Results And Conclusion:
Patients in the control group AOS was 1.69±0.17 mmol/L (median 1.72, interquartile range 1.53-1.83 mmol/L). With the development of IS AOS was 1.15±0,41 mmol/L (median 1.12; interquartile range 0.84-1.45 mmol/L) (p=0.000001). In groups with different pathogenetic mechanism of the IS value of the AOS was lower than in the control group and accounted for atherothrombotic variant (1.24; 0.98-1.67 mmol/L) (p=0.000001), for cardioembolic (p=0.000031), and for lacunar (1.24; 0.98-1.67 mmol/L) (p=0.035044). The value of the AOS was not significantly differ between men and women and was independent on the age and location of the ischemic lesion. Reduced AOS serum indicates an imbalance between prooksidatnoy and antioksidatnoy system in the formation of any pathogenic forms of IS. The decrease of AOS in blood serum indicates the balance between prooxidative and antioxidative system in the formation of any pathogenic forms of AI.
Related Concept Videos
01:29Stroke: Introduction and Types
01:15Ischemic Stroke l: Introduction
01:15Ischemic Stroke ll: Pathophysiology