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Related Experiment Videos

Anorexia in the elderly.

J E Morley1, A J Silver

  • 1Geriatric Research, Education and Clinical Center, Sepulveda VA Medical Center, CA 91343.

Neurobiology of Aging
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

A true anorexia of aging exists, distinct from disease-related causes. Neurotransmitter changes, like altered cholecystokinin and opioid activity, may underlie this condition in older adults.

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Area of Science:

  • Gerontology
  • Neuroscience
  • Gastroenterology

Background:

  • Unexplained weight loss and anorexia are common in the elderly population.
  • While often linked to disease, a distinct 'anorexia of aging' is suspected.

Purpose of the Study:

  • To explore the potential existence and underlying mechanisms of anorexia specifically related to the aging process.
  • To differentiate physiological anorexia of aging from anorexia caused by concurrent diseases.

Main Methods:

  • Review of animal studies investigating satiety and feeding drives in aged rodents.
  • Examination of neurotransmitter involvement in anorexia associated with depression and Alzheimer's disease in older individuals.

Main Results:

Related Experiment Videos

  • Animal models suggest older rodents exhibit heightened satiety from cholecystokinin and reduced opioid-driven feeding.
  • In some elderly individuals, anorexia is linked to depression, potentially involving excess corticotropin-releasing factor.
  • Alzheimer's disease patients may experience anorexia due to decreased norepinephrine and neuropeptide Y.

    • Conclusions:

    • Evidence supports a true anorexia of aging, influenced by neurobiological changes.
    • Specific neurotransmitter systems, including cholecystokinin, opioids, corticotropin-releasing factor, norepinephrine, and neuropeptide Y, are implicated in age-related anorexia.