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Presence of carcinogenic glutamic-acid pyrolysis products in human cataractous lens
S Manabe1, H Yanagisawa, Y Kanai
1Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo, Japan.
Ophthalmic Research
|January 1, 1988
Abstract:
The carcinogenic glutamic-acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2), were found to be present in human cataractous lenses, but not in normal bovine lenses. Contents of Glu-P-1 and Glu-P-2 in 35 human cataractous lenses were 832 and 20 ng, respectively. These results indicate that the human cataractous lens is exposed to the fluorescent compounds, carcinogenic glutamic pyrolysis products.