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Related Experiment Videos

Antidepressant drug studies in the elderly.

E Rockwell1, R W Lam, S Zisook

  • 1Department of Psychiatry, University of California, San Diego.

The Psychiatric Clinics of North America
|March 1, 1988
PubMed
Summary

Antidepressant drug trials in older adults show effectiveness for geriatric depression. Despite methodological issues in studies, these medications offer comparable side effects to younger populations.

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Area of Science:

  • Geriatric Psychiatry
  • Clinical Pharmacology

Background:

  • Limited research exists on antidepressant efficacy and safety specifically in elderly populations.
  • Existing trials often lack rigorous methodology, impacting reliability.

Purpose of the Study:

  • To review existing literature on antidepressant drug trials in individuals over 60.
  • To identify methodological limitations in geriatric depression studies.

Main Methods:

  • Literature review of antidepressant trials in elderly subjects.
  • Analysis of studies involving cyclic antidepressants, MAOIs, and psychostimulants.

Main Results:

  • Only 27 studies specifically focused on subjects over 60.
  • Common methodological flaws include poor diagnostic criteria and inadequate control for confounding factors.
  • Second-generation antidepressants were frequently compared to placebo or TCAs.

Conclusions:

  • Antidepressant medications are effective for treating depression in the elderly.
  • Adverse effects in older adults are generally comparable to those in younger patients.

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