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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

2.5K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Types02:20

Blood Types

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Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
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Related Experiment Video

Updated: Feb 21, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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Blood Quality Diagnostic Device Detects Storage Differences Between Donors.

Vivek P Jani, Shawn Mailo, Ali Athar

    IEEE Transactions on Biomedical Circuits and Systems
    |October 6, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Red blood cell (RBC) filterability, a measure of cell deformability, is a more sensitive indicator of donated blood quality deterioration than standard biochemical tests. This finding is crucial for managing blood banks and ensuring transfusion safety.

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    Area of Science:

    • Biomedical Engineering
    • Hematology
    • Blood Banking

    Background:

    • Millions of blood units are transfused annually, yet global blood shortages are projected to rise.
    • Donated blood quality varies, and current methods lack the ability to detect time-dependent changes in red blood cells (RBCs).
    • Assessing RBC deterioration rates is critical for optimizing blood storage and transfusion efficacy.

    Purpose of the Study:

    • To investigate interdonor variability in RBC quality over six weeks of storage.
    • To compare the sensitivity of RBC filterability and conventional biochemical tests in detecting blood quality changes.
    • To identify reliable markers for monitoring the deterioration of stored RBCs.

    Main Methods:

    • Nine units of RBCs were stored for six weeks, with weekly in vitro quality assessments.
    • Conventional biochemical tests (free Hb, K+, ATP, P50, 2,3 DPG, lactate, pH) were performed.
    • RBC deformability was measured using a cell filtration assay with a 5.0-μm pore membrane at various flow rates.

    Main Results:

    • No baseline interdonor variability was observed in biochemical or mechanical parameters.
    • Interdonor variability in biochemical properties emerged after 14 days of storage.
    • Significant declines in RBC filterability were detected as early as 7 days, indicating faster deterioration than biochemical markers.
    • Deterioration rates varied significantly among donors, with filterability proving more sensitive than biochemical assays.

    Conclusions:

    • RBC filterability is a more sensitive indicator of stored blood quality degradation than conventional biochemical tests.
    • Interdonor variability in RBC deterioration rates necessitates improved methods for quality assessment.
    • Enhanced monitoring of RBC mechanical properties can improve blood banking practices and transfusion safety.