Ultracompact Microwatt CMOS Current Readout With Picoampere Noise and Kilohertz Bandwidth for Biosensor Arrays

High-density on-chip electrochemical biosensor arrays are advancing toward a crucial role in health monitoring and development of new medicines and medical treatments. Nanopore and ion channel based sensors especially have great potential but present demanding resolution/speed/power/area requirements on instrumentation circuits. This paper presents a pixel-level current readout circuit and new group-cluster architecture to address the circuit challenges in high-performance biosensor arrays. Fabricated in 0.5 μm CMOS, this electrochemical voltammetry circuit achieves 7.2 pA_rms noise in an 11.5-kHz bandwidth and only consumes 21-μ W power and 0.06 mm² area per readout channel. Cyclic voltammetry experiments in a potassium ferricyanide solution and patch-clamp whole-cell experiments were performed to validate the circuit's feasibility for electrochemical biosensor applications.