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Updated: Feb 21, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
Published on: January 7, 2019
Nanoprecipitation for Poorly Water-Soluble Drugs
Tuong N G Nguyen1, Van-Thanh Tran2, Wei Duan3
1Chung-Ang University, Seoul. Korea.
Background:
More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.
Methods:
Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.
Results:
However, there are two technical issues of concern related to this method. First, the two solvents used for this approach must be miscible; concomitantly, the drug has to be soluble enough in a solvent but not in the antisolvent. Second, the particle growth needs to be adjusted by surfactant addition.
Conclusion:
In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble drugs will be discussed.
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