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Ankylosing Spondylitis Among Familial Mediterranean Fever Patients

Mira Merashli1, Mohammad Hassan A Noureldine2, Yehia Tfayli3

  • 1Department of Internal Medicine, Division of Rheumatology, American University of Beirut, Beirut, Lebanon.

Endocrine, Metabolic & Immune Disorders Drug Targets
|October 7, 2017
PubMed
Abstract

Insights

Familial Mediterranean Fever (FMF) patients show a variable prevalence of ankylosing spondylitis (AS). MEFV gene mutations are significantly linked to AS, often in human leucocyte antigen B27 (HLA-B27) negative individuals.

Area of Science:

  • Rheumatology
  • Genetics
  • Auto-inflammatory Diseases

Background:

  • Familial Mediterranean Fever (FMF) is a common hereditary auto-inflammatory disease.
  • Recurrent FMF attacks involve fever, abdominal pain, and arthritis.
  • The association between FMF and ankylosing spondylitis (AS) prevalence is debated.

Purpose of the Study:

  • To review existing literature on the relationship between AS and FMF.
  • To summarize data on AS prevalence in FMF patients.
  • To investigate the link between MEFV gene mutations and AS.

Main Methods:

  • Comprehensive literature search of PubMed and Embase databases.
  • Data collection from 1963 to 2017.
  • Analysis of studies examining the connection between AS and FMF.

Main Results:

  • AS prevalence in FMF patients is highly variable.
  • A significant association exists between MEFV gene mutations and AS.
  • Most co-occurring MEFV mutations and AS cases were HLA-B27 negative.

Conclusions:

  • Further large-scale population studies are required.
  • Investigate MEFV gene mutations in AS patients.
  • Assess AS prevalence and the impact of MEFV mutations on disease course in FMF patients.
Keywords:
Familial mediterranean feverHLA-B27MEFVankylosing spondylitissacroiliitis.spondyloarhtopathyspondyloarthritis

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