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Updated: Feb 21, 2026

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
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A versatile covalent organic framework-based platform for sensing biomolecules.

Wei Li1, Cheng-Xiong Yang, Xiu-Ping Yan

  • 1College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Nankai University, 94 Weijin Road, Tianjin 300071, China.

Chemical Communications (Cambridge, England)
|October 7, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed a versatile covalent organic framework (COF) platform for detecting biomolecules. This novel system demonstrates highly sensitive and selective fluorescence turn-on detection for DNA and adenosine 5'-triphosphate.

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Biochemistry

Background:

  • Covalent organic frameworks (COFs) offer tunable properties for advanced applications.
  • Sensing biomolecules like DNA and ATP is crucial for diagnostics and research.
  • Developing selective and sensitive detection platforms remains a key challenge.

Purpose of the Study:

  • To design and demonstrate a versatile COF-based platform for biomolecule sensing.
  • To achieve highly sensitive and selective detection of specific biomolecules.
  • To validate the platform's performance using DNA and adenosine 5 omino-triphosphate (ATP) as targets.

Main Methods:

  • Synthesis of a functionalized covalent organic framework (COF).
  • Development of a fluorescence turn-on sensing mechanism.
  • Experimental validation using target biomolecules (DNA and ATP).

Main Results:

  • The COF-based platform exhibited high sensitivity and selectivity for target biomolecules.
  • Successful demonstration of fluorescence turn-on detection for DNA.
  • Successful demonstration of fluorescence turn-on detection for adenosine 5 omino-triphosphate (ATP).

Conclusions:

  • The developed COF platform is a versatile tool for sensitive and selective biomolecule detection.
  • This approach offers a promising strategy for developing advanced biosensors.
  • The platform shows potential for applications in biological and medical diagnostics.