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A third human CALC (pseudo)gene on chromosome 11.

J W Höppener1, P H Steenbergh, J Zandberg

  • 1Institute of Molecular Biology, State University of Utrecht, The Netherlands.

FEBS Letters
|June 6, 1988
PubMed
Summary
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A new human gene, CALC-III, was identified on chromosome 11. This gene shows homology to calcitonin (CT) and calcitonin gene-related peptide (CGRP) genes but is likely a non-functional pseudogene.

Area of Science:

  • Genomics
  • Molecular Biology
  • Human Genetics

Background:

  • The calcitonin (CT) gene (CALC-I) produces CT or calcitonin gene-related peptide (CGRP) depending on tissue-specific expression.
  • A second gene, CALC-II, also produces a human CGRP but likely not a second CT.
  • Both CALC-I and CALC-II genes are located on human chromosome 11.

Purpose of the Study:

  • To describe a newly identified genomic locus in humans, designated CALC-III.
  • To investigate the homology and potential function of the CALC-III gene in relation to known CT and CGRP genes.

Main Methods:

  • Genomic sequence analysis
  • Homology comparison with CALC-I and CALC-II genes

Main Results:

Related Experiment Videos

  • Identification of the CALC-III genomic locus containing sequences homologous to exons 2 and 3 of CALC-I and CALC-II.
  • CALC-III gene lacks apparent coding capacity for CT or CGRP polypeptide hormones.
  • CALC-III is located on human chromosome 11, similar to CALC-I and CALC-II.

Conclusions:

  • The CALC-III gene is likely a pseudogene due to its inability to encode functional CT or CGRP.
  • The discovery adds to the understanding of the human calcitonin gene family and its evolution.