Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

3.0K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The sex difference in the reproductive response to starvation in <i>Drosophila melanogaster</i> is primarily located in the periphery rather than the nervous system.

American journal of physiology. Regulatory, integrative and comparative physiology·2025
Same author

Short-term 24h dietary recalls from observational studies cannot support claims on mortality.

Diabetes & metabolic syndrome·2025
Same author

Measurement-based care in an adolescent partial hospitalization program: Exploring treatment progress and predictors using the top problems assessment.

Evidence-based practice in child and adolescent mental health·2025
Same author

A pre-post trial to examine biological mechanisms of the effects of time-restricted eating on symptoms and quality of life in bipolar disorder.

BMC psychiatry·2024
Same author

Development of a Cell-Based Reporter Potency Assay for Live Virus Vaccines.

Vaccines·2024
Same author

Metabolic pathways that mediate the effects of food deprivation on reproductive behavior in female <i>Drosophila melanogaster</i>.

American journal of physiology. Regulatory, integrative and comparative physiology·2024

Related Experiment Video

Updated: Feb 21, 2026

Fat Preference: A Novel Model of Eating Behavior in Rats
05:57

Fat Preference: A Novel Model of Eating Behavior in Rats

Published on: June 27, 2014

13.8K

RFamide-related Peptide-3 and the Trade-off between Reproductive and Ingestive Behavior.

Jill E Schneider1, Noah A Benton1, Kim A Russo2

  • 1Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA.

Integrative and Comparative Biology
|October 7, 2017
PubMed
Summary

When food is scarce, animals prioritize eating over sex. Mild food restriction triggers a trade-off in motivated behaviors, orchestrated by RFamide-related peptide 3 (RFRP-3) and ovarian steroids.

More Related Videos

Combining Quantitative Food-intake Assays and Forcibly Activating Neurons to Study Appetite in Drosophila
07:24

Combining Quantitative Food-intake Assays and Forcibly Activating Neurons to Study Appetite in Drosophila

Published on: April 24, 2018

8.8K
A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
11:36

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

9.9K

Related Experiment Videos

Last Updated: Feb 21, 2026

Fat Preference: A Novel Model of Eating Behavior in Rats
05:57

Fat Preference: A Novel Model of Eating Behavior in Rats

Published on: June 27, 2014

13.8K
Combining Quantitative Food-intake Assays and Forcibly Activating Neurons to Study Appetite in Drosophila
07:24

Combining Quantitative Food-intake Assays and Forcibly Activating Neurons to Study Appetite in Drosophila

Published on: April 24, 2018

8.8K
A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
11:36

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

9.9K

Area of Science:

  • Neuroendocrinology
  • Behavioral Biology
  • Reproductive Science

Background:

  • Ingestive and sex behaviors are crucial for survival and reproduction.
  • Limited environmental energy often forces a trade-off, prioritizing ingestive over sex behaviors.
  • The effects of mild energetic challenges on these behaviors and their underlying mechanisms are not well understood.

Purpose of the Study:

  • To investigate if a trade-off between sex and ingestive behavior occurs even with mild food restriction.
  • To determine if mild energetic challenges affect appetitive but not consummatory ingestive and sex behaviors.
  • To explore the role of RFamide-related peptide 3 (RFRP-3) and ovarian steroids in orchestrating this trade-off.

Main Methods:

  • Utilized Syrian hamsters subjected to varying degrees of food restriction and re-feeding.
  • Assessed activation of RFRP-3-immunoreactive cells in the dorsomedial hypothalamus.
  • Measured changes in appetitive behaviors (food hoarding, sexual motivation) and consummatory behaviors (food intake, lordosis).
  • Examined the influence of ovarian steroids (estradiol, progesterone) on these responses.

Main Results:

  • A dose-response relationship was observed between food restriction/re-feeding and RFRP-3 cell activation and appetitive behaviors.
  • Consummatory behaviors (food intake, lordosis) were not significantly affected by mild food restriction.
  • Ovarian steroids modulated the effect of food restriction on RFRP-3 cell activation, particularly around estrus.
  • Intracerebral RFRP-3 administration decreased sexual motivation and increased food hoarding.

Conclusions:

  • Mild energetic challenges induce a trade-off between appetitive ingestive and sex behaviors, not consummatory ones.
  • RFamide-related peptide 3 (RFRP-3) and ovarian steroids play a key role in mediating these behavioral trade-offs.
  • This system likely helps animals adapt to fluctuating environmental energy availability.