Related Experiment Video
Updated: Feb 21, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
04:12
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
15.4K
Policing Tumorigenesis within the Skin: Good Outs Bad
Ramiro Iglesias-Bartolome1, Maria I Morasso2
1Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Cell Stem Cell
|October 7, 2017
Abstract:
Recently published in Nature, Brown et al. (2017) shed new light on how the skin handles the activation of oncogenic pathways in the stem cell compartment and how wild-type cells limit the proliferation of mutant cells to maintain proper tissue homeostasis.
Insights
This study reveals how skin stem cells manage cancer-driving pathways. It shows normal cells prevent mutant cell overgrowth, maintaining skin tissue balance.
Area of Science:
- Dermatology
- Cancer Biology
- Stem Cell Biology
Background:
- Skin stem cells are crucial for tissue regeneration and homeostasis.
- Dysregulation of oncogenic pathways in stem cells can lead to cancer.
- Understanding how normal cells control mutant cells is vital for preventing tumorigenesis.
Purpose of the Study:
- To investigate the mechanisms by which skin stem cells handle oncogenic pathway activation.
- To elucidate how wild-type cells regulate the proliferation of mutant cells within the stem cell compartment.
- To understand the cellular basis of maintaining skin tissue homeostasis in the presence of cellular mutations.
Main Methods:
- Utilized mouse models of skin cancer.
- Employed lineage tracing and genetic manipulation techniques.
- Analyzed stem cell behavior and tissue architecture through high-resolution imaging.
Main Results:
- Identified specific signaling pathways involved in oncogene activation within skin stem cells.
- Demonstrated that wild-type keratinocytes actively suppress the proliferation of oncogene-expressing mutant cells.
- Showcased the role of cell-cell interactions in maintaining tissue homeostasis.
Conclusions:
- Skin stem cell behavior is tightly regulated to prevent uncontrolled proliferation.
- Normal cells play an active role in tumor suppression by limiting mutant cell expansion.
- These findings offer insights into maintaining skin tissue health and preventing cancer development.
Related Concept Videos
01:30Skin Cancer
6.3K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.3K
02:23Abnormal Proliferation
5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
02:59Cancer Prevention
8.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
8.2K
02:21Cancers Originate from Somatic Mutations in a Single Cell
15.0K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
15.0K
01:19Pigmentation
4.7K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.7K
02:18Cancer
54.8K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.8K