Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pleiotropy

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

Disorders of the Nervous Tissue

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...

Dysrhythmias II: Classification of Tachyarrhythmias

Dysrhythmias II: Classification of Tachyarrhythmias

Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...

Cardiovascular System Abnormal Findings I: Inspection and Palpation

Cardiovascular System Abnormal Findings I: Inspection and Palpation

In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Deciphering Freezing of Gait: What Neuropathology Reveals About an Episodic Phenomenon.

The European journal of neuroscience·2026

Same author

Cognitive, Motor and Oculomotor Contributions to the Trail Making Test in Progressive Supranuclear Palsy.

Movement disorders clinical practice·2026

Same author

A multimodal biomarker strategy to enhance diagnostic precision in neurodegenerative parkinsonism.

Nature medicine·2026

Same author

Distinct neuroinflammatory profiles in progressive supranuclear palsy associated with <i>HLA</i> haplotypes.

Brain communications·2026

Same author

The prevalence of Lewy body pathology across nine international community-based cohorts.

Brain : a journal of neurology·2026

Same author

A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.

Nature genetics·2026

Same journal

Preface.

Handbook of clinical neurology·2026

Same journal

Foreword.

Handbook of clinical neurology·2026

Same journal

Fundus autofluorescence imaging.

Handbook of clinical neurology·2026

Same journal

The electroretinogram as a means to study the physiology of the retina.

Handbook of clinical neurology·2026

Same journal

Adaptive optics scanning light ophthalmoscopy.

Handbook of clinical neurology·2026

Same journal

Modeling the human retina in a dish: Advances and future directions.

Handbook of clinical neurology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 21, 2026

Author Spotlight: Understanding the Impact of Pathological Proteins on Axonal Transport in Neurodegenerative Diseases

Author Spotlight: Understanding the Impact of Pathological Proteins on Axonal Transport in Neurodegenerative Diseases

Published on: December 22, 2023

Tauopathies.

Gabor G Kovacs¹

¹Institute of Neurology, Medical University of Vienna, Vienna, Austria.

Handbook of Clinical Neurology

|October 9, 2017

Summary

This summary is machine-generated.

Tauopathies involve abnormal tau protein buildup in the brain, extending beyond known forms to include emerging conditions like chronic traumatic encephalopathy (CTE). Understanding this broad spectrum is crucial for diagnosis and developing new therapies.

Keywords:

Pick disease aging-related tau astrogliopathy argyrophilic grain disease corticobasal degeneration globular glial tauopathy primary age-related tauopathy progressive supranuclear palsy tau tauopathy

More Related Videos

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

Related Experiment Videos

Last Updated: Feb 21, 2026

Author Spotlight: Understanding the Impact of Pathological Proteins on Axonal Transport in Neurodegenerative Diseases

Author Spotlight: Understanding the Impact of Pathological Proteins on Axonal Transport in Neurodegenerative Diseases

Published on: December 22, 2023

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

Area of Science:

Neuropathology
Neurodegenerative Diseases
Tau Protein Biology

Background:

Tauopathies are defined by abnormal tau protein aggregation in the brain.
The spectrum of tauopathies is broader than previously recognized, encompassing emerging entities.
These include globular glial tauopathies, primary age-related tauopathy, CTE, and aging-related tau astrogliopathy.

Purpose of the Study:

To delineate the expanding spectrum of tauopathies.
To highlight emerging tau pathologies and their clinical presentations.
To discuss diagnostic approaches and pathogenetic concepts.

Main Methods:

Review of existing literature and neuropathologic findings.
Analysis of clinical symptoms associated with various tauopathies.
Consideration of emerging pathogenetic concepts like cell-to-cell propagation.

Main Results:

Identified emerging tauopathies such as globular glial tauopathies, primary age-related tauopathy, CTE, and aging-related tau astrogliopathy.
Documented a wide range of clinical symptoms, including frontotemporal dementia and parkinsonism.
Highlighted the potential role of cell-to-cell propagation in tauopathy pathogenesis.
Recommended specific brain regions (hippocampus, amygdala, basal ganglia) for cost-effective screening.
Suggested genetic background investigation for atypical tau pathologies.

Conclusions:

The spectrum of tauopathies is diverse and expanding, requiring updated diagnostic and research approaches.
Cell-to-cell propagation offers a novel perspective on tauopathy pathogenesis and potential therapeutic targets.
Multidisciplinary research is essential to fully understand and manage the diverse range of tauopathies.